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REVIEW article
Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 12 - 2025 |
doi: 10.3389/fvets.2025.1453150
This article is part of the Research Topic The application of new technologies such as new vaccines, therapeutic cytokines and antibodies, and antiviral drugs in the prevention and treatment of animal infectious diseases View all 11 articles
Current status of recombinant duck enteritis virus vector vaccine research
Provisionally accepted- Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China
Duck enteritis virus (DEV), the pathogen of duck viral enteritis, belongs to the α-herpesvirus subfamily. Like other herpesviruses, it has a large genome with multiple non-coding and non-essential regions for viral replication. It is suitable as a live virus vector for inserting and expressing antigenic genes from other pathogens to develop multivalent vaccines. With the advancement of molecular biology research and experimental technology, genetic modification of the DEV genome has matured, leading to the successful construction of recombinant DEV live vector vaccines. These vaccines have demonstrated the ability to resist DEV and other pathogens, showing potential as recombinant viral vaccine vectors and playing a crucial role in the development of new avian vaccines. This article provides an overview of the progress of research on recombinant vaccines using DEV as the vector. It includes the biological characteristics of DEV and its advantages and limitations as a vaccine vector, methods for constructing recombinant DEV, the technical platform for efficiently building recombinant DEV, factors affecting the immune protection efficacy of recombinant DEV, and the application of recombinant DEV in vaccine development. Aiming to provide a reference for the development of duck enteritis virus vector-based vaccines.
Keywords: Duck enteritis virus, Recombinant vector vaccine, genetic modification, waterfowl infectious disease, immune protection efficacy, Avian vaccines
Received: 22 Jun 2024; Accepted: 24 Jan 2025.
Copyright: © 2025 Jia, Wang, Wu, Lei, Cheng and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
An-Ping Wang, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China
Zhi Wu, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China
Yu-Ting Cheng, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China
Shanyuan Zhu, Jiangsu Agri-animal Husbandry Vocational College, Taizhou, China
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