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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1521424

Proinflammatory cytokines Interleukin-18 and interleukin-6 mediate anorexia induction by trichothecene deoxynivalenol and its congeners

Provisionally accepted
Chuang Zhou Chuang Zhou 1Zihui Qin Zihui Qin 2Huayue Zhang Huayue Zhang 2Huiping Xiao Huiping Xiao 2*Hua Zhang Hua Zhang 1*
  • 1 Jiangsu Vocational College of Agriculture and Forestry, Jurong, China
  • 2 School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    As the common foodborne mycotoxins with the highest pollution rate, deoxynivalenol (DON, also named “vomitoxin”) can harm the health of humans and animals by causing anorectic response. It has four congeners: 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV), and fusarenon X (FX). These five mycotoxins have been associated with the detrimental effect on food intake. However, its underlying mechanism of anorexia remains unclear. The goal of this research was to compare the anorectic responses to these five mycotoxins and relate these effects to proinflammatory cytokines interleukin-18 (IL-18) and interleukin-6 (IL-6) following intraperitoneal (IP) and oral exposure to a common dose at 2.5 mg/kg BW in mice. Plasma IL-18 and IL-6 were elevated within 1-2 h and returned to basal levels at 6 h after exposure to DON, 3-ADON and 15-ADON. FX promoted IL-18 expression at 6 h.Whereas, FX only promoted IL-6 at 6 h. When NIV was injected intraperitoneally, IL-18 started to rise at 1 h and peaked at 6 h. Whereas, NIV only promoted IL-18 at 2 h following oral exposure. IP exposure to NIV induced an increase in IL-6 that occurred only at 2 h. No effect on IL-6 when exposed orally to NIV. In conclusion, the data indicate that IL-18 and IL-6 play critical roles in anorectic response induced by DON and its four congeners 3-ADON, 15-ADON, NIV, FX.

    Keywords: Deoxynivalenol, Trichothecene, Anorexia, Interleukin-18, Interleukin-6

    Received: 01 Nov 2024; Accepted: 20 Nov 2024.

    Copyright: © 2024 Zhou, Qin, Zhang, Xiao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huiping Xiao, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230601, Anhui Province, China
    Hua Zhang, Jiangsu Vocational College of Agriculture and Forestry, Jurong, China

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