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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1515977

Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida-induced vascular inflammatory injury in mice

Provisionally accepted
Qirong Lu Qirong Lu *Luyao Wang Luyao Wang Xueping Jiang Xueping Jiang Wantong Han Wantong Han Pu Guo Pu Guo Yu Liu Yu Liu Shulin Fu Shulin Fu Jianglin Xiong Jianglin Xiong Zhongyuan Wu Zhongyuan Wu Yinsheng Qiu Yinsheng Qiu
  • Wuhan Polytechnic University, Wuhan, China

The final, formatted version of the article will be published soon.

    Pasteurella multocida (Pm) is a widespread zoonotic pathogen with the ability to infect wild animals, livestock, and humans. Pm infection can cause haemorrhagic pneumonia, indicating that the pathogenesis involves serious vascular injury and inflammation. 18β-Glycyrrhetinic acid (GA) has cardiovascular protective and antiinflammatory effects, but its effect on vascular injury caused by Pm infection is not clear. This study focused on the protective effects of GA on Pm-induced vascular inflammatory injury in mice. The results showed that GA intervention significantly improved the survival rate and the changes in haematological and biochemical parameters caused by Pm infection in mice. Haematoxylin and eosin staining revealed that GA delayed the progression of vascular injury, including abnormalities in elastic fibres, local rupture of the vascular intima, and inflammatory cell infiltration in response to Pm infection. The immunohistochemical results showed that after the GA intervention, the vascular inflammatory response in Pm-infected mice was alleviated.These protective effects may be related to the reduced expression of poly (ADP-ribose) polymerase-1, high mobility group box 1, interleukin-1β, and interleukin-18 in vascular tissue by GA. These findings suggest that GA inhibits the activation of inflammation to protect vascular injury in vivo. Hence, GA exhibits therapeutic potential in the treatment of vascular injury.

    Keywords: 18β-glycyrrhetinic acid, Inflammatory Response, Pasteurella multocida, protective effects, vascular injury

    Received: 23 Oct 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Lu, Wang, Jiang, Han, Guo, Liu, Fu, Xiong, Wu and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qirong Lu, Wuhan Polytechnic University, Wuhan, China

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