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BRIEF RESEARCH REPORT article

Front. Vet. Sci.
Sec. Animal Reproduction - Theriogenology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1506029

Improving Fertilization Rates in IVF Using Rutin and Quercetin in Preculture Medium or Through Oral Administration

Provisionally accepted
Hiromitsu Tanaka Hiromitsu Tanaka *Satona Ichihara Satona Ichihara
  • Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan

The final, formatted version of the article will be published soon.

    Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study, the effects of rutin and quercetin on fertility and pregnancy rates were investigated by incorporating these compounds into the preculture medium for in vitro fertilization (IVF) or administering them orally to mice.The addition of rutin and quercetin to the preculture medium increased the IVF fertilization rate by more than twofold. Oral administration of rutin and quercetin to aged male and nulliparous female mice improved pregnancy outcomes. These findings have important implications for the non-invasive treatment of infertility.

    Keywords: Flavonoid, Infertility, IVF, Pregnancy, Quercetin, ROS, rutin Abbreviations: IVF, in vitro fertilization; ROS

    Received: 15 Oct 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Tanaka and Ichihara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hiromitsu Tanaka, Faculty of Pharmaceutical Sciences, Nagasaki International University, Nagasaki, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.