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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Emergency and Critical Care Medicine
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1505479

Utilization of peripheral glucose and lactate differences in the diagnosis of feline arterial thromboembolism: a multi-center study

Provisionally accepted
Michael Yee Michael Yee 1Julien Guillaumin Julien Guillaumin 2Meredith 't Hoen Meredith 't Hoen 1*Jiazhang Cai Jiazhang Cai 3Jonathan Mochel Jonathan Mochel 3Rebecca Walton Rebecca Walton 1
  • 1 Iowa State University, Ames, United States
  • 2 Colorado State University, Fort Collins, Colorado, United States
  • 3 University of Georgia, Athens, Georgia, United States

The final, formatted version of the article will be published soon.

    Objective: To establish lactate and glucose differences between affected and non-affected limbs in cats with feline arterial thromboembolism (FATE). To evaluate the correlation between these values and survival to discharge as well as congestive heart failure (CHF). Methods: Blood glucose and lactate concentrations were prospectively obtained on admission from client-owned FATE cats and client-owned cats presented for other conditions. The glucose and lactate concentrations of the front limbs (or non-affected) and the hind limbs (or affected) were measured. Lactate (Δlactate) and glucose (Δglucose) differences between the two limbs were calculated. Results: The FATE group and control groups included 18 and 41 cats, respectively. The median age of the cats within the FATE group and control groups was 9.5 years and 5 years, respectively. The median Δlactate was significantly higher in the FATE group than in the control group (7.2 mmol/L versus 0.1 mmol/L, respectively; p=<0.01). The median Δglucose was significantly higher in the FATE group than in the control group (155 mg/dL versus 3mg/dL, respectively; P=<0.01). A diagnosis of FATE was made using a ∆lactate cutoff of 2.2 mmol/L (100% sensitivity and 95% specificity) or a ∆glucose cutoff of 41 mg/dL (100% sensitivity and specificity). There was no correlation between Δlactate and Δglucose and survival to discharge. A higher ∆glucose was significantly associated with concurrent CHF (P=0.01). Conclusion: Both Δlactate and Δglucose were accurate diagnostic tools for cats with FATE. Neither were correlated with survival to discharge. Higher Δglucose values were significantly associated with the presence of CHF.

    Keywords: Thrombosis, saddle thrombus, cardiomyopathy, Hypercoagulability, delta, Differential

    Received: 02 Oct 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Yee, Guillaumin, 't Hoen, Cai, Mochel and Walton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meredith 't Hoen, Iowa State University, Ames, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.