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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Infectious Diseases
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1496316

Recombinant Characteristics and Pathogenicity of a Novel PRRSV Variant in Weaned Piglets Derived from Recombination of Three Clinical Epidemic Strains

Provisionally accepted
Yalin Yang Yalin Yang 1Longshuai Yao Longshuai Yao 2Xinyuan Wang Xinyuan Wang 2Xinrong Dong Xinrong Dong 1Gang Wang Gang Wang 2Ying Yu Ying Yu 1*
  • 1 Qingdao Agricultural University, Qingdao, China
  • 2 Shandong Agricultural University, Taian, Shandong Province, China

The final, formatted version of the article will be published soon.

    The recent emergence of PRRSV strains NADC30 and NADC34, along with their recombination with HP-PRRSV-like strains, has added complexity to PRRS control strategies on swine farms. Given the high variability and recombination potential of PRRSV, continuous monitoring of the virus's clinical epidemiology is essential for effective prevention and control. This study isolated a PRRSV variant, designated SDVD-NMG2023, from approximately 65-day-old pigs, showing a mortality rate of around 15% within the herd. Phylogenetic and molecular evolutionary analyses revealed a natural recombination event involving the NADC30, NADC34, and JXA1 strains. Piglets infected with SDVD-NMG2023 exhibited mild clinical symptoms, including elevated rectal temperatures in two out of five piglets, as well as cough, mild anorexia, weight stunting, interstitial pneumonia, and thymic atrophy in all cases. The findings obtained here suggest that the novel crossbred PRRSV isolate SDVD-NMG2023, derived from three prevalent clinical strains, may induce more unusual clinical presentations compared to those associated with HP-PRRS, albeit still impacting the health of the herd by causing immunosuppression. This study provides critical insights into the emergence of multi-strain PRRSV recombination, particularly between NADC30/34-like and HP-PRRSV-like strains, supporting a more strategic and comprehensive approach to PRRS prevention and control.

    Keywords: PRRSV, NADC30, NADC34, recombination, pathogenicity

    Received: 06 Oct 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Yang, Yao, Wang, Dong, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ying Yu, Qingdao Agricultural University, Qingdao, China

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