The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Livestock Genomics
Volume 11 - 2024 |
doi: 10.3389/fvets.2024.1493284
This article is part of the Research Topic Genetic Dissection of Meat Quality and Production Performance in Pig View all articles
Integrated Transcriptomic and Metabolomic Analyses Reveal Heterosis for Meat Quality of Neijiang Pigs
Provisionally accepted
Haifeng Dan
1
Chengming Liu
1*
Huiling Zhang
1*
Mailin Gan
1*
Yan Wang
1*
Lei Chen
1*
Ye Zhao
1
Bin Liu
2*
Kangping Zhu
2*
Lili Niu
1
Li Zhu
1*
Linyuan Shen
1*- 1 Sichuan Agricultural University, Ya'an, China
- 2 Sichuan Dekang Agriculture and Animal Husbandry Food Group Co. LTD, Chengdu, Sichuan Province, China
Obese pig breeds have excellent meat quality, while lean pig breeds have high lean meat percentage and feed conversion rate. However, due to their respective shortcomings, obese pig and lean pig breeds are unable to balance production and consumption needs. Therefore, this study crossbred Neijiang (NJ) pigs from Chinese obese pig breeds with Large White（LW） pigs from lean pigs to produce Neijiang × Large White (NL) pigs, and compared the differences in carcass and meat quality traits between NJ pigs and NL pigs. The results showed that the carcass performance of NL pigs was significantly higher than that of NJ pigs, and the excellent meat quality characteristics of NJ pigs were also retained on NL pigs. In order to explore the potential regulatory mechanisms of these differences, a comprehensive analysis of the longissimus dorsi muscle of NJ pigs was conducted for the first time through transcriptomics and metabolomics, and compared with NL pigs. A total of 635 differentially expressed genes（DEGs）and 11 significantly different metabolites （SDMs）were identified. The results of multi omics joint analysis showed that betaine, uridine triphosphate, glycerol 3-phosphate, and glutathione in SDMs were enriched in the shared KEGG pathway and significantly correlated with C1QTNF12, GGA3, SLC16A6, and RXRG in DEGs. In general, it is feasible to enhance the production performance of NJ pigs through crossbreeding with LW pigs. The hybrid offspring inherit the advantages of these two varieties, maintaining excellent meat quality while also having better carcass performance.
Keywords: pig, Carcass characteristic, meat quality, Transcriptomics, Metabolomics, hybridization
Received: 08 Sep 2024; Accepted: 05 Nov 2024.
Copyright: © 2024 Dan, Liu, Zhang, Gan, Wang, Chen, Zhao, Liu, Zhu, Niu, Zhu and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chengming Liu, Sichuan Agricultural University, Ya'an, China
Huiling Zhang, Sichuan Agricultural University, Ya'an, China
Mailin Gan, Sichuan Agricultural University, Ya'an, China
Yan Wang, Sichuan Agricultural University, Ya'an, China
Lei Chen, Sichuan Agricultural University, Ya'an, China
Bin Liu, Sichuan Dekang Agriculture and Animal Husbandry Food Group Co. LTD, Chengdu, 610207, Sichuan Province, China
Kangping Zhu, Sichuan Dekang Agriculture and Animal Husbandry Food Group Co. LTD, Chengdu, 610207, Sichuan Province, China
Li Zhu, Sichuan Agricultural University, Ya'an, China
Linyuan Shen, Sichuan Agricultural University, Ya'an, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.