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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Epidemiology and Economics
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1481809

Retrospective Research: identifying and conducting phylogenetic analyses on 4 Orf virus strains isolated in Yunnan province between 2021 and 2023 -revealing their significance and characteristic features

Provisionally accepted
Jiarui Xie Jiarui Xie Meilin kou Meilin kou *yinan wang yinan wang xianghang su xianghang su *huafeng gao huafeng gao *haisheng miao haisheng miao *
  • Yunnan Animal Science and Veterinary Institute, Kunming, China

The final, formatted version of the article will be published soon.

    Contagious Eczema (CE), caused by ORFV, impacts sheep and goats globally, with severe symptoms and economic losses. The ORFV situation in Yunnan, China, was unclear before 2021 -2023 study.11 scab samples from goats on small farms in three Yunnan municipalities were collected. Four ORFV strains were isolated and characterized using scanning electron microscopy, cytopathic effect observation, and PCR.Phylogenetic analyses of ORFV011 and ORFV059 genes showed significant results. For ORFV011, the nucleotide similarity of the four strains to D1701 strain was 98.4% -99%. For ORFV059, it was 97.2% -97.9% with OV-SA00 strain.These findings suggest gene rearrangements and interactions among strains during Yunnan's ORFV outbreak, forming a unique evolutionary lineage.Our study is the first comprehensive one on Yunnan's ORFV prevalence with in-depth phylogenetic analysis. It has important implications. In vaccine development, understanding genetic variances helps create better vaccines. For disease control, customized strategies like targeted quarantine and disinfection can be designed based on strain characteristics. From a public health aspect, as CE is zoonotic, closely monitoring ORFV in goats aids in predicting and preventing human infections, thus being significant for protecting goats against CE in Yunnan.

    Keywords: Contagious eczema, Orf virus, ORFV011, ORFV059, Phylogenetic 28 analysis 29

    Received: 19 Aug 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Xie, kou, wang, su, gao and miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Meilin kou, Yunnan Animal Science and Veterinary Institute, Kunming, China
    xianghang su, Yunnan Animal Science and Veterinary Institute, Kunming, China
    huafeng gao, Yunnan Animal Science and Veterinary Institute, Kunming, China
    haisheng miao, Yunnan Animal Science and Veterinary Institute, Kunming, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.