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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Animal Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1477970

Toxicity of standing milkvetch infected with Alternaria gansuense to white mice

Provisionally accepted
Bo Yang Bo Yang Zhi Biao Nan Zhi Biao Nan Yan Zhong Li Yan Zhong Li *
  • Lanzhou University, Lanzhou, China

The final, formatted version of the article will be published soon.

    Standing milkvetch (Astragalus adsurgens) is widely distributed in the wild in Eurasia and North America and has been bred for cultivated forage in China. Yellow stunt and root rot disease caused by Alternaria gansuense is the primary disease of standing milkvetch. A. gansuense promotes the production of swainsonine in the plant.This study aimed to determine the safety of standing milkvetch that is infected with A. gansuense as forage for animals. Two-week-old specific pathogen-free (SPF) male white mice were fed a commercial mouse feed (CMF), healthy plant feed (HPF) and diseased plant feed (DPF) for 3 or 6 weeks. We observed histological changes in the liver and kidney tissues of the mice and measured their daily feed intake, daily water intake, body weight, feed utilization, organ coefficients, and activities of serum enzymes. The results showed that the daily feed intake of the mice that were fed DPF and HPF was significantly higher (P<0.05) than those fed CMF at 3 and 6 weeks. The highest increase was observed in the daily water intake of the mice fed HPF (P<0.05) followed by DPF and CMF. However, the mice fed DPF gained the least weight

    Keywords: Diseased plant, Feeding experiment, Hematology, Histology, Serum enzyme, Toxicity

    Received: 09 Aug 2024; Accepted: 11 Dec 2024.

    Copyright: © 2024 Yang, Nan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yan Zhong Li, Lanzhou University, Lanzhou, China

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