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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1477575

Dietary supplementation with Bacillus subtilis KC1 alleviates the negative effects of Mycoplasma gallisepticum on growth performance and amino acid metabolism of broiler chickens

Provisionally accepted
Xueping Chen Xueping Chen Jiayao Cui Jiayao Cui Yuanyuan Wang Yuanyuan Wang Keguang Han Keguang Han Nairui Huo Nairui Huo Jian Wang Jian Wang *
  • Shanxi Agricultural University, Jinzhong, Shanxi Province, China

The final, formatted version of the article will be published soon.

    The aim of this study was to explore whether and how Bacillus subtilis KC1 can enhance the growth performance of Mycoplasma gallisepticum (MG)-infected broilers.Broilers were randomly divided into 4 groups: the control group (basal diet), the MG group (basal diet + MG challenge), the KC group (basal diet + Bacillus subtilis KC1 supplementation), the KC + MG group (basal diet + Bacillus subtilis KC1 supplementation + MG challenge). The results showed that, compared to the control group, MG group exhibited significantly reduced body weight and average daily gain, and increased feed conversion ratio of broilers. However, compared to the MG group, the Bacillus subtilis KC1 + MG group exhibited significantly improved above indicators of growth performance. In addition, compared to the MG group, Bacillus subtilis KC1 + MG group exhibited increased superoxide dismutase levels and reduced levels of malondialdehyde, interleukin-1β, and tumor necrosis factor-α of broilers. Furthermore, metabolomics and transcriptomics analyses indicated that MG infection disrupted amino acid metabolism in broilers, whereas Bacillus subtilis KC1 supplementation alleviated the abnormal amino acid metabolism caused by MG.These results suggested that Bacillus subtilis KC1 may alleviate the poor growth performance caused by MG infection in broilers by improving amino acid metabolism.

    Keywords: Bacillus subtilis, Mycoplasma gallisepticum, Amino acid, Metabolomics, Transcriptomics

    Received: 08 Aug 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Chen, Cui, Wang, Han, Huo and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jian Wang, Shanxi Agricultural University, Jinzhong, Shanxi Province, China

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