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BRIEF RESEARCH REPORT article

Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1471590

Evaluating Biomarkers in Canine Cytotoxic Interface Dermatitis Reactions to Account for Clinical and Histopathological Similarities and Differences

Provisionally accepted
Shriya Kannan Shriya Kannan 1Neil Beatchang Wong Neil Beatchang Wong 1Grace E Ryan Grace E Ryan 1Nia E R James Nia E R James 1Ayodeji Ajayi Ayodeji Ajayi 1Janet E Lubov Janet E Lubov 1Clement N David Clement N David 2Linda Wrijil Linda Wrijil 3Nicholas A Robinson Nicholas A Robinson 3Kelly Hughes Kelly Hughes 4Ramon Almela Ramon Almela 3Jillian M Richmond Jillian M Richmond 1*
  • 1 University of Massachusetts Medical School, Worcester, United States
  • 2 NanoString Technologies, Seattle, Washington, United States
  • 3 Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, United States
  • 4 Veterinary Diagnostic Laboratory, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States

The final, formatted version of the article will be published soon.

    Cytotoxic Interface Dermatitis (CID) is a pattern reaction predominantly at the dermoepidermal junction that encapsulates numerous chronic noncommunicable inflammatory skin conditions in which the basal keratinocytes are attacked by T-cell infiltrate leading to apoptosis, lymphocytic satellitosis and vacuolar degeneration. Though many diseases include CID, the type of clinical presentation and tissue patterns expressed from disease to disease varies. In this study, we evaluate the commonalities and discrepancies in significantly expressed biomarkers across several CID conditions to examine their impact on clinical presentations in canines. Among the uniquely expressed genes in each disease, we observed significantly expressed IFNG in Discoid Lupus Erythematosus, TRAT1 in Epitheliotropic Lymphoma, and CXCL8 and CSF3R in pemphigus affected dogs. With this knowledge, we may be able to use molecular signatures in combination with current treatment practices to develop a more targeted treatment plan for patients with CID.Studying uniquely expressed genes in cutaneous disorders to understand clinical inflammation patterns in canines.

    Keywords: Cytotoxic Interface Dermatitis (CID), Discoid lupus erythematosus (DLE), epitheliotropic lymphoma (EL)/cutaneous T cell lymphoma (CTCL), Pemphigus, Erythema Multiforme, Voght-Koyanagi Harada (VKH), canine (dog), pharmaco-transcriptomics

    Received: 27 Jul 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Kannan, Wong, Ryan, James, Ajayi, Lubov, David, Wrijil, Robinson, Hughes, Almela and Richmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jillian M Richmond, University of Massachusetts Medical School, Worcester, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.