AUTHOR=Qiao Yang-Yang , Wang Hai-Ming , Lu Hui , Wang Yong-Juan , Zhang Wei , Gu Hao , Cai Xue-Hui , Xu Qin-Se , Chen Zhang-Yan , Tang Yan-Dong 

TITLE=Generation of an infectious cDNA clone for NADC30-like PRRSV

JOURNAL=Frontiers in Veterinary Science

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1468981

DOI=10.3389/fvets.2024.1468981

ISSN=2297-1769

ABSTRACT=<p>The porcine reproductive and respiratory syndrome virus (PRRSV) is a highly significant infectious disease that poses a substantial threat to the global pig industry. In recent years, the NADC30-like strain has gradually emerged as prevalent in China, causing a profound impact on the country’s pig farming industry. Therefore, it is important to conduct an in-depth study on the characteristics and gene functions of the NADC30-like strain. An infectious cDNA clone is an indispensable tool for investigating the functions of viral genes. In this current study, we successfully isolated a NADC30-like strain and constructed its full-length infectious cDNA clone. The utilization of this clone will facilitate our investigation into the viral replication, pathogenesis, and immune response associated with the PRRSV NADC30-like strain.</p>