Skip to main content

ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1464432
This article is part of the Research Topic Camelid Farming, Production, Reproduction, Health, and Welfare View all 9 articles

The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke -induced chronic obstructive pulmonary disease model in rat

Provisionally accepted
Sepide Behrouz Sepide Behrouz 1Mahla Mohammadi Mahla Mohammadi 1Hadi Sarir Hadi Sarir 2Mohammad Hossein Boskabady Mohammad Hossein Boskabady 1*
  • 1 Mashhad University of Medical Sciences, Mashhad, Razavi Khorasan, Iran
  • 2 University of Birjand, Birjand, Iran

The final, formatted version of the article will be published soon.

    Running head: Camel milk improve systemic oxidative stress of COPD rats Background: The effects of camel milk in inflammation and systemic oxidative stress of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) associated with small airway inflammation in rats were investigated. Methods: 35 male Wistar rats were randomly divided into five groups: a) control, b) CSexposed rats, c and d) CS-exposed rats treated with the 4 and 8 ml/kg camel milk, and e) CSexposed rats treated with 1mg/kg dexamethasone. Results: Total and differential WBC counts, serum level of TNF-α and malondialdehyde (MDA) level in serum and homogenized tissues of the heart, kidney, liver, and testicle were significantly increased, but catalase (CAT), superoxide dismutase (SOD) and thiol levels were significantly decreased in CS-exposed rats (P<0.01 to P<0.001). Treatment with dexamethasone and both doses of camel milk improved all measured variables compared to the COPD group (P<0.05 to P<0.001). The improvements of most variables in the treated group with high dose of camel milk were higher than the effect of dexamethasone (P<0.05 to P<0.001). These findings suggest that camel milk has a therapeutic potential for treating systemic oxidative stress and inflammatory induced by CS. Conclusion: Therefore, camel milk might be effective in attenuating the effects of CS-induced systemic inflammation and oxidative stress.

    Keywords: Camel milk, COPD, cytokine, oxidative stress, pulmonary disease CAT, Catalase, COPD, chronic obstructive pulmonary disease, CS, cigarette smoke, CYP, Cyclophosphamide, ELISA, enzyme-linked immunosorbent assay, Gpx, glutathione peroxidase, LAB, lactic acid bacteria, MDA, malondialdehyde

    Received: 14 Jul 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Behrouz, Mohammadi, Sarir and Boskabady. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mohammad Hossein Boskabady, Mashhad University of Medical Sciences, Mashhad, 91778 9919, Razavi Khorasan, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.