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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1463889

Speckle tracking echocardiography for evaluation of myocardial functions before and after mitral valvuloplasty in dogs

Provisionally accepted
Sho Fukuzumi Sho Fukuzumi 1,2Ahmed S. Mandour Ahmed S. Mandour 3Ahmed Farag Ahmed Farag 2Tomohiko Yoshida Tomohiko Yoshida 4Akitsugu Nishiura Akitsugu Nishiura 5*Hideki Yotsuida Hideki Yotsuida 6*Yota Yaginuma Yota Yaginuma 7*Katsuhiro Matsuura Katsuhiro Matsuura 8*Ryou Tanaka Ryou Tanaka 2*
  • 1 VCA Japan Dolphin Animal Hospital Urawamisono, saitama, Japan
  • 2 Tokyo University of Agriculture and Technology, Fuchu, Japan
  • 3 Suez Canal University, Ismaïlia, Ismailia, Egypt
  • 4 Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan
  • 5 Ashiya Limone Animal Hospital, ashiya, Japan
  • 6 Osaka National Hospital (NHO), Osaka, Japan
  • 7 VCA Japan Shiraishi Animal Hospital, sayama, Japan
  • 8 College of Veterinary Medicine, University of Florida, Gainesville, Florida, United States

The final, formatted version of the article will be published soon.

    Background: Myxomatous mitral valve disease (MMVD) is the most common acquired heart disease in dogs. Mitral valvuloplasty (MVP) addresses regurgitation, but the pre-and postoperative changes in myocardial function remain uncertain.Objectives: This study evaluated myocardial motion before and after MVP using speckle tracking echocardiography (2D-STE).Animals: Eight client-owned dogs undergoing MVP for MMVD.Methods: Myocardial deformation was assessed by 2D-STE before surgery and at 1-and 3-months post-surgery. Measurements included left ventricular global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), cardiac twist, and right ventricular free wall GLS (RVFW-GLS).Results: Postoperative decreases were observed in left ventricular internal dimensions, left atrial size, and early diastolic myocardial velocity, with an increase in peak late diastolic velocity. LV-GLS decreased at 1 month (-14.4%) and 3 months (-16.3%) compared to preoperative values (-24.4%) (P =0.0078, P =0.015). GCS decreased at 1 month (-12.9%) and 3 months (-14.8%) compared to preoperative values (-21.7%) (P =0.0078). GRS decreased at 1 month (27.7%) and 3 months (32.0%) compared to preoperative values (67.7%) (P=0.0078). No significant changes were observed in RVFW-GLS. Peak systolic twist increased at 3 months (9.1° vs. 4.9°, P =0.039). Peak systolic apical rotation showed an upward trend at 3 months (P=0.109). Left ventricular twist was mildly affected by LVIDd, LVIDDN, and sphericity index (R² =0.187, P =0.034; R² =0.33, P =0.0029; R² =0.22, P =0.019).Postoperative myocardial motion approached reference values, indicating significant improvement, particularly in left ventricular twisting motion. These findings highlight the positive impact of surgery on cardiac function in dogs with MMVD.

    Keywords: Mitral valve repair, 2D-STE, Twist, GLS, GCS, GRS, ventricular interaction

    Received: 28 Aug 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Fukuzumi, Mandour, Farag, Yoshida, Nishiura, Yotsuida, Yaginuma, Matsuura and Tanaka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Akitsugu Nishiura, Ashiya Limone Animal Hospital, ashiya, Japan
    Hideki Yotsuida, Osaka National Hospital (NHO), Osaka, 540-0006, Japan
    Yota Yaginuma, VCA Japan Shiraishi Animal Hospital, sayama, Japan
    Katsuhiro Matsuura, College of Veterinary Medicine, University of Florida, Gainesville, 32608, Florida, United States
    Ryou Tanaka, Tokyo University of Agriculture and Technology, Fuchu, Japan

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