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ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Anesthesiology and Animal Pain Management
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1461628
This article is part of the Research Topic Pain Assessment and Management in Veterinary Medicine View all 8 articles

Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain

Provisionally accepted
Masataka Enomoto Masataka Enomoto 1Jonathan Hash Jonathan Hash 1Tracey Cole Tracey Cole 1Maria D. Porcel Sanchez Maria D. Porcel Sanchez 1Andrea Thomson Andrea Thomson 1Erin Perry Erin Perry 1Savannah Aker Savannah Aker 1Aoi Nakanishi Aoi Nakanishi 1Emily Haupt Emily Haupt 1Logan Opperman Logan Opperman 1Simon Roe Simon Roe 1Nichola A. Thompson Nichola A. Thompson 2John F. Innes John F. Innes 3B. Duncan X. Lascelles B. Duncan X. Lascelles 1*
  • 1 North Carolina State University, Raleigh, United States
  • 2 Elanco Animal Health, Hook, United Kingdom
  • 3 Movement Independent Veterinary Referrals, Cheshire, United Kingdom

The final, formatted version of the article will be published soon.

    The response to medical management of young dogs with osteoarthritis (OA) associated pain has not been evaluated. Using an open-label design, the effectiveness, over a 4-month period, of standardized management (grapiprant/fish oil/exercise) for treating OA pain in young dogs was evaluated. Included dogs were 9 months-4 years of age; ≥3.6kg body weight; had ≥1 appendicular joint with radiographic OA and obvious joint pain; had a Liverpool Osteoarthritis in Dogs (LOAD) score of ≥5. The non-steroidal anti-inflammatory piprant (grapiprant) was given at the recommended dose daily, omega-3 fatty acid supplementation was initiated at 100mg/kg and then increased to 200mg/kg daily, and leash exercise was gradually increased to a target of 60 mins daily. Client-reported outcome measures (CROMs) and force plate gait analysis were collected at baseline and monthly for 4 months. The index limb was defined as the most severely affected limb at baseline. Forty-eight dogs were enrolled (mean ±SD age of 30.7 ±10.7 months).Hips, elbows, and stifles were commonly affected. Medication and supplement compliance was excellent (≥95% of target administered), and treatments were well-tolerated. CROMs showed significant improvement over time and at each time point. Overall, peak vertical force (PVF) increased significantly (<0.001), and vertical impulse increased numerically. Increase in PVF from baseline was significant at all time points except 4-months. This study demonstrates a clinically meaningful benefit of a multimodal treatment regimen over a 4-month period for young dogs (<4 years old) with OA-pain. Future work should determine if early, effective treatment is of long-term benefit.

    Keywords: Osteoarthritis, Pain, dog, Grapiprant, Force plate, fish oil, Exercise

    Received: 08 Jul 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Enomoto, Hash, Cole, Porcel Sanchez, Thomson, Perry, Aker, Nakanishi, Haupt, Opperman, Roe, Thompson, Innes and Lascelles. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: B. Duncan X. Lascelles, North Carolina State University, Raleigh, United States

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