Skip to main content

ORIGINAL RESEARCH article

Front. Vet. Sci.
Sec. Livestock Genomics
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1461075
This article is part of the Research Topic Enhancing Livestock Breeding through Advanced Genetic Tools and Phenotyping Systems View all articles

Genome-wide Association Studies for Milk Production Traits and Persistency of First Calving Holstein Cattle in Türkiye

Provisionally accepted
Metin Erdoğan Metin Erdoğan 1Samet Çinkaya Samet Çinkaya 1*Bertram Brenig Bertram Brenig 2Koray Çelikeloğlu Koray Çelikeloğlu 1Mustafa Demirtaş Mustafa Demirtaş 1Suat Sarıibrahimoğlu Suat Sarıibrahimoğlu 3Mustafa Tekerli Mustafa Tekerli 1
  • 1 Afyon Kocatepe University, Afyonkarahisar, Türkiye
  • 2 University of Göttingen, Göttingen, Lower Saxony, Germany
  • 3 Other, Çanakkale, Türkiye

The final, formatted version of the article will be published soon.

    The study presents a comprehensive investigation into the genetic determinants of 100-day milk yield (100DMY), 305-day milk yield (305DMY), total milk yield (TMY), and persistency using first lactation records of 374 Holstein heifers reared in a private farm at Çanakkale province of Türkiye, employing a genome-wide association study (GWAS) approach. The research underscores the substantial genetic component underlying these economically important traits through detailed descriptive statistics and heritability estimations. The estimated moderate to high heritabilities (0.32 -0.54) for milk production traits suggest the feasibility of targeted genetic improvement strategies. By leveraging GWAS, the study identifies many significant and suggestively significant single nucleotide polymorphisms (SNP) associated with studied traits. Noteworthy genes have identified in this analysis include BCAS3, MALRD1, CTNND2, DOCK1, TMEM132C, NRP1, CNTNAP2, GPRIN2, PLEKHA5, GLRA1, SCN7A, HHEX, and KTM2C, RAB40C, RAB11FIP3, and FXYD6. These findings provide valuable understandings of the genetic background of milk production and persistency in Holstein cattle, shedding light on specific genomic regions and candidate genes playing pivotal roles in these traits. This research contributes valuable knowledge to the field of dairy cattle genetics and informs future breeding efforts to improve milk production sustainability and efficiency in Holstein cattle populations.

    Keywords: GWAS, candidate genes, Milk production, Persistency, Holstein heifers, Cattle

    Received: 07 Jul 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Erdoğan, Çinkaya, Brenig, Çelikeloğlu, Demirtaş, Sarıibrahimoğlu and Tekerli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Samet Çinkaya, Afyon Kocatepe University, Afyonkarahisar, Türkiye

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.