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CASE REPORT article

Front. Vet. Sci.
Sec. Veterinary Pharmacology and Toxicology
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1448123
This article is part of the Research Topic Therapeutic Potential and Risks of Cannabinoids in Animal Health View all articles

Case Report: Treatment of non-medical tetrahydrocannabinol toxicosis with transmucosal cannabidiol-infused dissolving sheets in six dogs

Provisionally accepted
Kyra Marsigliano Kyra Marsigliano 1Katie Green Katie Green 1Brian Anthony DiGangi Brian Anthony DiGangi 2,3*
  • 1 Intracoastal West Vet, Jacksonville, United States
  • 2 College of Veterinary Medicine, University of Florida, Gainesville, United States
  • 3 University of Florida, Gainesville, Florida, United States

The final, formatted version of the article will be published soon.

    Increased cases of canine tetrahydrocannabinol (THC) toxicosis have been reported in North America in recent years. Cases are often evaluated on an emergency basis and treatment has relied upon supportive care which can be costly and prohibitive for some pet owners. The purpose of this report is to describe the clinical findings and outcomes in dogs with non-medical, presumptive THC toxicosis treated by administration of a cannibidiol (CBD)-infused transmucosal dissolving sheet. Medical records of six cases of non-medical, presumptive THC toxicosis from a private primary care practice and a private after-hours emergency practice were reviewed and summarized. Five of six cases were treated exclusively with transmucosal CBD (0.4-2.6 mg/kg); one case also received injectable anti-emetic therapy. Lethargy and ataxia noticeably improved and all additional clinical signs resolved within 45 minutes of treatment in five of six cases. No further follow-up measures for THC toxicosis were required in any case; one case required additional follow-up for presumably unrelated gastrointestinal distress. This is the first report of treatment of canine THC toxicosis by administration of CBD. The use of transmucosal CBD-infused dissolving sheets resulted in expedient resolution of clinical signs in a minimally invasive manner that is accessible to both clients and veterinary practitioners.

    Keywords: canine, marijuana toxicosis, thc, cbd, Transmucosal

    Received: 12 Jun 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Marsigliano, Green and DiGangi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Brian Anthony DiGangi, College of Veterinary Medicine, University of Florida, Gainesville, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.