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ORIGINAL RESEARCH article
Front. Vet. Sci.
Sec. Anesthesiology and Animal Pain Management
Volume 11 - 2024 |
doi: 10.3389/fvets.2024.1442670
Comparison of hemodynamic effects of propofol or alfaxalone during induction in dogs
Provisionally accepted- 1 Fossanese Veterinary Center, Fossano, Italy
- 2 Department of Veterinary Science – University of Turin, Grugliasco, Italy, Turin, Italy
- 3 Clinica veterinaria imperiese, Imperia, Italy
- 4 Veterinary Clinic Roma Sud, Rome, Sicily, Italy
This randomized prospective clinical study aimed to compare the hemodynamic effects of propofol and alfaxalone for the induction of anaesthesia in dogs. Thirty-one healthy dogs undergoing various procedures in a private referral centre were premedicated with intramuscular acepromazine (0.015 mg/kg) and methadone (0.15 mg/kg). They then received 5 mg/kg of propofol over 30 seconds for induction, followed by a maintenance dose of 25 mg/kg/h (Group P), or 2 mg/kg of alfaxalone over 30 seconds for induction, followed by a continuous rate infusion of 10 mg/kg/h (Group A). Heart rate (HR), mean arterial pressure (MAP), and the velocity time integral (VTI) of the aortic blood flow using transthoracic echocardiography were measured before anaesthetic induction and every 15 seconds for 180 seconds. Dogs not adequately anaesthetized for intubation were excluded from the hemodynamic evaluation. Events of bradycardia (HR < 60 beats/min) and hypotension (any MAP value lower than 60 mmHg) were also recorded. Statistical analyses utilized ANOVA for repeated measures, two-way repeated measures ANOVA, paired t-tests, or Wilcoxon signed rank-test as appropriate. Significance was set at p< 0.05. Two dogs in Group P (2/14) and 3 in Group A (3/17) were excluded from the study because the anaesthesia plane was too light to allow intubation. Treatment P resulted in a significant decrease in MAP between 45-75 seconds during the induction period, with no significant variation in HR, VTI, and VTI*HR. In treatment A, HR increases between 60-105 seconds, VTI decreases at 150-180 seconds. Analysis between groups didn’t show any difference in MAP (p=0.12), HR (p=0.10), VTI (p=0.22) and VTI*HR (p=0.74). During induction, hypotension was detected in 3/12 (25%) dogs in Group P and 1/14 (8%) in Group A. In healthy premedicated dogs, propofol and alfaxalone induction produce similar hemodynamic variations. Propofol induction results in a short-term reduction in MAP, whereas alfaxalone induction preserves MAP and cardiac output by significantly increasing heart rate.
Keywords: Alfaxalone, Propofol, Hemodynamic variation, dog, anaesthesia
Received: 02 Jun 2024; Accepted: 30 Aug 2024.
Copyright: © 2024 Sarotti, Lardone, Franci, Oricco and Rabozzi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Diego Sarotti, Fossanese Veterinary Center, Fossano, Italy
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