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SYSTEMATIC REVIEW article

Front. Vet. Sci.
Sec. Veterinary Epidemiology and Economics
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1437189

The first meta-analysis of the G96S single nucleotide polymorphism (SNP) of the prion protein gene (PRNP) with chronic wasting disease in white-tailed deer

Provisionally accepted
Sae-Young Won Sae-Young Won Yong-Chan Kim Yong-Chan Kim *
  • Andong National University, Andong, Republic of Korea

The final, formatted version of the article will be published soon.

    Background: Prion diseases are irreversible infectious neurodegenerative diseases caused by a contagious form of prion protein (PrP Sc ). Since chronic wasting disease (CWD)-infected white-tailed deer are strong carriers of the prion seed through corpses via scavenger animals, preemptive control based on genetic information for a culling system is necessary. However, the risk of CWD-related genetic variants has not been fully evaluated. In the present study, we carried out a quantitative estimation of the risk of a G96S single nucleotide polymorphism (SNP) of the PRNP gene to CWD infection in white-tailed deer.We carried out a literature search for genetic data of the G96S (c.286G>A) SNP of the PRNP gene from CWD-infected white-tailed deer and matched controls. We performed a meta-analysis using incorporated eligible studies to evaluate the association of the G96S SNP of the PRNP gene with susceptibility to CWD in white-tailed deer.We identified a strong association between the G96S (c.286G>A) SNP of the PRNP gene and susceptibility to CWD infection in white-tailed deer using meta-analysis. We observed the most significant association in the recessive model (odds ratio = 3.0050, 95% confidence interval: 2.0593; 4.3851, p < 0.0001), followed by the additive model (odds ratio = 2.7222, 95% confidence interval: 1.9028; 3.8945, p < 0.0001) and the heterozygote (AA vs. AG) comparison (odds ratio = 2.7405, 95% confidence interval: 1.9215; 3.9085, p < 0.0001).To the best of our knowledge, this was the first meta-analysis of the association between the G96S (c.286G>A) SNP of the PRNP gene and susceptibility to CWD infection.

    Keywords: prion, PRNP, PrP Sc, Scrapie, BSE, CWD, CJD, White-tailed deer

    Received: 24 May 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Won and Kim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yong-Chan Kim, Andong National University, Andong, Republic of Korea

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