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SYSTEMATIC REVIEW article
Front. Vet. Sci.
Sec. Veterinary Epidemiology and Economics
Volume 11 - 2024 |
doi: 10.3389/fvets.2024.1397145
Use of recombinant proteins for the diagnosis and prevention of Mycoplasma bovis: A systematic review
Provisionally accepted- 1 Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil
- 2 Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista, Bahia, Brazil
- 3 University of São Paulo, São Paulo, Rio Grande do Sul, Brazil
- 4 Federal University of Bahia (UFBA), Salvador, Brazil
Mycoplasma bovis is a highly contagious agent that causes various pathologies affecting herd animals' reproduction, production, and milk productivity-this systematic review aimed to analyze diagnostic alternatives and vaccine compounds based on recombinant proteins. SciELO, PubMed, and CAPES Periodicals Portal databases were searched using the PRISMA protocol. The inclusion criteria were:(1) the use of recombinant proteins for M. bovis identification or vaccine production, (2) the use of biological samples, (3) availability in the selected databases, (4) in vitro or in vivo nature of associated studies, (5) publication between 2008 and 2023, and (6) availability in English. Among the 53 studies selected, ten were relevant for the review, with four related to diagnosis and six related to vaccines. Regarding diagnosis, an indirect enzyme-linked immunosorbent assay (ELISA) using recombinant proteins was utilized in the studies, which achieved a sensitivity and specificity of > 90% for detecting M. bovis infection. However, developing recombinant vaccines for controlling M. bovis infections has not been successful. Further studies are required to determine the optimal adjuvant and challenge conditions for the protective effects of these antigens.
Keywords: Systematic review, Mycoplasma bovis, diagnosis, Vaccine, Recombinant Proteins
Received: 07 Mar 2024; Accepted: 28 Aug 2024.
Copyright: © 2024 Gomes, Da Silva, Junior, Santos Barbosa, Neves, Ribeiro, Bastos and Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lucas M. Marques, Federal University of Bahia (UFBA), Salvador, Brazil
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