AUTHOR=Li Shuang , Yu Na , Tang Yaoxin , Liu Chunshuang , Zhang Ying , Chen Xiaojie , Wu Hao , Li Xiubo , Liu Yiming 

TITLE=Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk

JOURNAL=Frontiers in Veterinary Science

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1384076

DOI=10.3389/fvets.2024.1384076

ISSN=2297-1769

ABSTRACT=<p>In this study, two intramammary infusions of cefquinome sulfate were investigated for pharmacokinetics and bioavailability. Twelve lactating cows for each group were administered an effective dose of 75 mg/gland for cefquinome, with milk samples collected at various time intervals. The concentrations of cefquinome in milk at different times were determined by the UPLC-MS/MS method. Analyses of noncompartmental pharmacokinetics were conducted on the concentration of cefquinome in milk. Mean pharmacokinetic parameters of group A and group B following intramammary administration were as follows: AUC<sub>last</sub> 300558.57 ± 25052.78 ng/mL and 266551.3 ± 50654.85 ng/mL, C<sub>max</sub> 51786.35 ± 11948.4 ng/mL and 59763.7 ± 8403.2 ng/mL, T<sub>1/2</sub> 5.69 ± 0.62 h and 5.25 ± 1.62 h, MRT 7.43 ± 0.79 h and 4.8 ± 0.78 h, respectively. Pharmacokinetic experiments showed that the relative bioavailability of group B was 88.69% that of group A. From our findings, group B (3 g: 75 mg) shows a quicker drug elimination process than group A (8 g: 75 mg), which suggests that the withdrawal period for the new formulation may be shorter.</p>