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CASE REPORT article

Front. Vet. Sci.
Sec. Comparative and Clinical Medicine
Volume 11 - 2024 | doi: 10.3389/fvets.2024.1373882

Successful Treatment of Intestinal Leiomyositis in a Dog using adjunctive Intravenous Immunoglobulin

Provisionally accepted
Michelle Patrick Olivarez Michelle Patrick Olivarez 1*Jarod Williams Jarod Williams 2*Nutnapong Udomteerasuwat Nutnapong Udomteerasuwat 3Sarah Corner Sarah Corner 3Christopher Byers Christopher Byers 4
  • 1 Southeast Veterinary Referral Center, Miami, FLA, United States
  • 2 Ozark Veterinary Specialty Care, Springdale, Arizona, United States
  • 3 Michigan State University, East Lansing, Michigan, United States
  • 4 CriticalCareDVM.com, Omaha, Nebraska, United States

The final, formatted version of the article will be published soon.

    A 10 year old female spayed Dachshund canine presented with abdominal pain and generalized severe ileus. Exploratory laparotomy performed confirming severe ileus of undetermined origin. Multiple intestinal biopsy results confirmed acute intestinal leiomyositis. IHC stains confirmed T-cell predominant inflammatory infiltrate.Intravenous immunoglobulin hIVIG was administered prior to immunosuppressive therapy. Return of functional peristaltic activity and resolution of symptoms was observed within 10-days of hIVIG treatment. Long term management with functional peristaltic recovery was achieved with combined therapy including mycophenolate.hIVIG treatment requires additional study to investigate potential benefit in the stabilization phase of this commonly fatal, treatment-refractory disease.

    Keywords: intestinal leiomyositis, Ileus, pseudo-obstruction, CIPO, Intravenous immunoglobulin (IVIg), Cholecystitis, T-cell activation

    Received: 20 Jan 2024; Accepted: 28 Jun 2024.

    Copyright: © 2024 Patrick Olivarez, Williams, Udomteerasuwat, Corner and Byers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Michelle Patrick Olivarez, Southeast Veterinary Referral Center, Miami, FLA, United States
    Jarod Williams, Ozark Veterinary Specialty Care, Springdale, Arizona, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.