AUTHOR=Choi Jinyoung , Chae Yeon , Kang Byeong-Teck , Lee Sungin 

TITLE=An evaluation of the physiological uptake range of 18F-fluoro-2-deoxy-D-glucose in normal ovaries of seven dogs using positron emission tomography/computed tomography

JOURNAL=Frontiers in Veterinary Science

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1343695

DOI=10.3389/fvets.2024.1343695

ISSN=2297-1769

ABSTRACT=<sec id="sec1"><title>Introduction</title><p>This study evaluated the physiological uptake range of <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) in the normal ovaries of seven dogs using positron emission tomography/computed tomography (PET/CT).</p></sec><sec id="sec2"><title>Materials and methods</title><p>The dogs were subjected to general anesthesia and were positioned in ventral recumbency for PET/CT scans. The dosage of <sup>18</sup>F-FDG ranged from 0.14 to 0.17 mCi/kg and was administered intravenously followed by 0.9% NaCl flushing; PET/CT images of each dog were obtained precisely 60 min after the injection of <sup>18</sup>F-FDG. The regions of interest were drawn manually, and standardized uptake values (SUV) were calculated to evaluate the <sup>18</sup>F-FDG uptake in each ovary. The maximum and mean SUVs (SUV max and SUV mean) for all the ovaries of the dogs were then computed.</p></sec><sec id="sec3"><title>Results</title><p>The range of SUV max and SUV mean of the normal ovaries of the dogs were 1.28–1.62 and 1.07–1.31 (mean ± standard deviation), respectively.</p></sec><sec id="sec4"><title>Conclusion</title><p>This is the first study to investigate the normal <sup>18</sup>F-FDG uptake baseline data of normal canine ovaries using PET/CT scans. These data will help clinicians in identifying malignant tumors before anatomical changes in the ovary through PET/CT scans.</p></sec>