AUTHOR=Dubbert Tamino , Meester Marina , Smith Richard Piers , Tobias Tijs J. , Di Bartolo Ilaria , Johne Reimar , Pavoni Enrico , Krumova-Valcheva Gergana , Sassu Elena Lucia , Prigge Christopher , Aprea Giuseppe , May Hannah , Althof Nadine , Ianiro Giovanni , Żmudzki Jacek , Dimitrova Albena , Alborali Giovanni Loris , D'Angelantonio Daniela , Scattolini Silvia , Battistelli Noemi , Burow Elke TITLE=Biosecurity measures to control hepatitis E virus on European pig farms JOURNAL=Frontiers in Veterinary Science VOLUME=11 YEAR=2024 URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2024.1328284 DOI=10.3389/fvets.2024.1328284 ISSN=2297-1769 ABSTRACT=
Hepatitis E virus (HEV) genotype 3 is a prevalent zoonotic pathogen in European pig farms, posing a significant public health risk primarily through the foodborne route. The study aimed to identify effective biosecurity measures for controlling HEV transmission on pig farms, addressing a critical gap in current knowledge. Utilizing a cross-sectional design, fecal samples from gilts, dry sows, and fatteners were collected on 231 pig farms of all farm types across nine European countries. Real-time RT-PCR was employed to test these samples for HEV. Simultaneously, a comprehensive biosecurity questionnaire captured data on various potential measures to control HEV. The dependent variable was HEV risk, categorized as lower or higher based on the percentage of positive pooled fecal samples on each farm (25% cut-off). The data were analyzed using generalized linear models (one for finisher samples and one for all samples) with a logit link function with country and farm type as