AUTHOR=Giles Claire B. , Ferdous Farha , Halleran Jennifer L. , Yeatts Jim L. , Baynes Ronald E. , Mzyk Danielle A. 

TITLE=Flunixin meglumine tissue residues after intravenous administration in goats

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2024

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1341779

DOI=10.3389/fvets.2023.1341779

ISSN=2297-1769

ABSTRACT=<sec><title>Background</title><p>Flunixin is commonly used in goats in an extra-label manner, indicating a significant need to determine withdrawal intervals for edible tissues.</p></sec><sec><title>Objective</title><p>The objectives of the present study were to investigate the depletion of flunixin meglumine in various goat tissues, including the liver, kidney, fat, and muscle.</p></sec><sec><title>Methods</title><p>Twenty Boer goats were enrolled and administered an intravenous dose (2.2 mg/kg) of flunixin meglumine. Five animals were randomly euthanized at 24, 48, 72, or 96 h following dosing. All samples were analyzed via ultra-performance liquid chromatography coupled with mass spectrometry.</p></sec><sec><title>Results</title><p>The concentration of flunixin in all tissues declined rapidly, with the highest mean concentrations quantified in the kidney (0.137 ± 0.062 μg/g) and liver (0.077 ± 0.029 μg/g) tissues at 24 h.</p></sec><sec><title>Conclusion</title><p>Since any detection of flunixin residues at slaughter found in goat tissues is considered a violative residue, a conservative withdrawal interval of 17 days was calculated to ensure levels of flunixin fell below the regulatory limits of detection in liver, kidney, and muscle tissues.</p></sec>