AUTHOR=Tan Lei , Wang Kaixin , Bai Ping , Zhang Shuo , Zuo Mengting , Shu Xianghua , Wang Aibing , Yao Jun 

TITLE=Host cellular factors involved in pseudorabies virus attachment and entry: a mini review

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1314624

DOI=10.3389/fvets.2023.1314624

ISSN=2297-1769

ABSTRACT=<p>Pseudorabies virus (PRV) belongs to the <italic>Alphaherpesvirinae</italic> subfamily and serves as an exceptional animal model for investigating the infection mechanism of Herpes simplex virus type 1. Notably, PRV has the capability to infect a wide range of mammals, including humans, highlighting its potential as an overlooked zoonotic pathogen. The attachment and entry steps of PRV into host cells are crucial to accomplish its life cycle, which involve numerous cellular factors. In this mini review, we offer a comprehensive summary of current researches pertaining to the role of cellular factors in PRV attachment and entry stages, with the overarching goal of advancing the development of novel antiviral agents against this pathogen.</p>