Rui M. Gil da Costa
Ana Lúcia Abreu-Silva- 1Postgraduate Programme in Health Sciences (PPGCS), Federal University of Maranhão (UFMA), São Luís, Brazil
- 2Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP), Health Research Network (RISE)@CI-IPOP, Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal
- 3Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering, University of Porto, Porto, Portugal
- 4Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto, Porto, Portugal
- 5Department of Pathology, State University of Maranhão, São Luís, Brazil
Editorial on the Research Topic
Biology and pathology of tumor viruses in animals, volume II
This second volume of the Biology and pathology of tumor viruses in animals Research Topic was built upon the success of the first volume and aimed to proceed the discussion of viral agents involved in tumorigenesis. As with the first volume, researchers from different countries contributed original research that add to the current scientific knowledge in this field, as well as a research article that provides a systematic approach to specific oncoviruses. In this volume, four articles were dedicated to papillomaviruses and one to the bovine leukemia virus.
Peruchi Fernandes et al. contributed an interesting case report describing and unusual mixed infection of bovine papillomaviruses types 2 and 4 (BPV2 and BPV4) in upper alimentary papillomas in a cow. The authors call the reader's attention to the involvement of those viral types in digestive papillomatosis, even in the absence of Pteridium spp. and its carcinogens, which are known to contribute for this kind of lesions (1).
Daraban Bocaneti et al.(a) studied bovine cutaneous fibropapillomas associated with BPV2 and described the expression patterns of metalloproteinases (MMPs) 2, 7, 4 and 14 and their tissue inhibitors (TIMPs) 1 and 2. The authors reported that BPV2-positive fibropapillomas show up-regulation of MMP2, MMP7 and MMP9 and down-regulation of MMP14, TIMP1 and TIMP2. The active forms of MMP2 and MMP9 were detected, and the authors suggest that an imbalance between these MMPs and their TIMPs is implicated in the pathogenesis of bovine cutaneous fibropapillomas associated with BPV2.
The same team contributed a related study soon after. In that study, Daraban Bocaneti et al.(b) described the expression patterns of MMP1, MMP8, MMP13, and TIMP3 in bovine fibropapillomas associated with BPV2. The authors observed an up-regulation of MMP8 and MMP13 and down-regulation of MMP1 and TIMP3 in tumor tissues compared with normal skin, further implicating an imbalance between MMPs and their TIMPs in the pathogenesis of bovine fibropapillomas.
Still regarding papillomaviruses, Medeiros-Fonseca et al. contributed a mini review that provides an update on the current knowledge about canine and feline papillomaviruses. The authors described lesions associated with the 24 known canine papillomavirus (CPV) and six feline papillomavirus (FcaPV) genotypes.
Gomes Pereira et al. reported the prevalence of bovine leukemia virus (BLV) infection in cattle from the Brazilian state of Maranhão. The authors found that approximately 9% of tested animals were positive for BLV and were infected with BLV genotype 6.
Overall, the works included in the second volume of this Research Topic contribute to deepen our knowledge of tumor viruses in animals, including their distribution and mechanisms of pathogenesis.
Author contributions
RG: Writing—original draft, Writing—review and editing. AA-S: Writing—original draft, Writing—review and editing.
Funding
This research was funded by the European Investment Fund, the FEDER/COMPETE/POCI—Operational Competitiveness and Internationalization Program, and national funds from the FCT—Portuguese Foundation for Science and Technology under projects UID/AGR/04033/2020 and UIDB/CVT/00772/2020. This work was also supported by LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE), funded by national funds through FCT/MCTES (PIDDAC) and 2SMART (NORTE-01-0145- FEDER-000054) and supported by the Norte Portugal Regional Operational Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF). RG received a FAPEMA postdoctoral grant (BPD-01343/23). AA-S holds a productivity scholarship from CNPq (grant number 13348/2021-9).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Keywords: tumor virus, avian leukemia virus, papillomavirus, pathology, cancer
Citation: Gil da Costa RM and Abreu-Silva AL (2023) Editorial: Biology and pathology of tumor viruses in animals, volume II. Front. Vet. Sci. 10:1286103. doi: 10.3389/fvets.2023.1286103
Received: 30 August 2023; Accepted: 04 September 2023;
Published: 14 September 2023.
Edited and reviewed by: Francisco Javier Salguero, UK Health Security Agency (UKHSA), United Kingdom
Copyright © 2023 Gil da Costa and Abreu-Silva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rui M. Gil da Costa, rui.costa@ufma.br