AUTHOR=Yun Taesik , Chae Yeon , Koo Yoonhoi , Lee Dohee , Kim Hakhyun , Yang Mhan-Pyo , Kang Byeong-Teck 

TITLE=Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1284306

DOI=10.3389/fvets.2023.1284306

ISSN=2297-1769

ABSTRACT=<p>Neurofilament light chain (NfL) is a neuroaxonal protein in the nervous system. NfL has recently been demonstrated to be a biomarker for various neurological diseases. In this study, we investigated the potential role of NfL in hypoxia-induced neuronal injury in dogs. Serum NfL levels were determined using a single-molecule array. Serum NfL concentrations were significantly higher in hypoxemic dogs without neurological signs (<italic>n</italic> = 6, 175.5 pg/mL) than in healthy dogs (<italic>n</italic> = 15, 15.9 pg/mL; <italic>p</italic> &lt; 0.0001). Therefore, neuronal injury should be considered in dogs with hypoxemia caused by cardiopulmonary diseases, even in the absence of neurological signs.</p>