AUTHOR=Soto Perezchica María M. , Guerrero Barrera Alma L. , Avelar Gonzalez Francisco J. , Quezada Tristan Teodulo , Macias Marin Osvaldo 

TITLE=Actinobacillus pleuropneumoniae, surface proteins and virulence: a review

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1276712

DOI=10.3389/fvets.2023.1276712

ISSN=2297-1769

ABSTRACT=<p><italic>Actinobacillus pleuropneumoniae</italic> (App) is a globally distributed Gram-negative bacterium that produces porcine pleuropneumonia. This highly contagious disease produces high morbidity and mortality in the swine industry. However, no effective vaccine exists to prevent it. The infection caused by App provokes characteristic lesions, such as edema, inflammation, hemorrhage, and necrosis, that involve different virulence factors. The colonization and invasion of host surfaces involved structures and proteins such as outer membrane vesicles (OMVs), pili, flagella, adhesins, outer membrane proteins (OMPs), also participates proteases, autotransporters, and lipoproteins. The recent findings on surface structures and proteins described in this review highlight them as potential immunogens for vaccine development.</p>