AUTHOR=Wang Qian , Song Xiaoyue , Bi Yi , Zhu Haijing , Wu Xianfeng , Guo Zhengang , Liu Mei , Pan Chuanying 

TITLE=Detection distribution of CNVs of SNX29 in three goat breeds and their associations with growth traits

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1132833

DOI=10.3389/fvets.2023.1132833

ISSN=2297-1769

ABSTRACT=<p>As a member of the SNX family, the <italic>goat sorting nexin 29</italic> (<italic>SNX29</italic>) is initially identified as a myogenesis gene. Therefore, this study aimed to examine the polymorphism in the <italic>SNX29</italic> gene and its association with growth traits. In this study, we used an online platform to predict the structures of the <italic>SNX29</italic> protein and used quantitative real-time PCR to detect potential copy number variation (CNV) in Shaanbei white cashmere (SBWC) goats (<italic>n</italic> = 541), Guizhou black (GB) goats (<italic>n</italic> = 48), and Nubian (NB) goats (<italic>n</italic> = 39). The results showed that goat <italic>SNX29</italic> protein belonged to non-secretory protein. Then, five CNVs were detected, and their association with growth traits was analyzed. In SBWC goats, CNV1, CNV3, CNV4, and CNV5 were associated with chest width and body length (<italic>P</italic> &lt; 0.05). Among them, the CNV1 individuals with gain and loss genotypes were superior to those individuals with a median genotype, but CNV4 and CNV5 of individuals with the median genotype were superior to those with the loss and gain genotypes. In addition, individuals with the gain genotype had superior growth traits in CNV3. In brief, this study suggests that the CNV of <italic>SNX29</italic> can be used as a molecular marker in goat breeding.</p>