AUTHOR=Shirahata So , Iwashita Naoki , Sasaki Rie , Nomura Ryota , Murakami Masaru , Yasuda Junya , Yasuda Hidemi , Nakajima Kuniyasu , Inaba Hiroaki , Matsumoto-Nakano Michiyo , Nakano Kazuhiko , Uchiyama Jumpei , Fukuyama Tomoki 

TITLE=Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

JOURNAL=Frontiers in Veterinary Science

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2023.1022838

DOI=10.3389/fvets.2023.1022838

ISSN=2297-1769

ABSTRACT=<p>Previous research has demonstrated that <italic>Porphyromonas gulae (P. gulae)</italic> significantly contributes to the development of periodontal disease in dogs. <italic>Porphyromonas gulae</italic> is divided into three subtypes according to the 41-kDa filamentous appendage (<italic>fimA</italic>), defined as types A, B, and C. This study aimed to elucidate the association between <italic>fimA</italic> type of <italic>P. gulae</italic> with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by <italic>P. gulae fimA</italic> type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in <italic>P. gulae</italic>-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in <italic>P. gulae fimA</italic> type C-dominant dogs was significantly lower than that of <italic>P. gulae</italic>-negative dogs, suggesting there is a significant association between <italic>fimA</italic> type of <italic>P. gulae</italic> and the number of permanent teeth resulting from the development of periodontal disease.</p>