AUTHOR=Klein-Richers Ute , Heitland Annika , Hartmann Katrin , Dörfelt René 

TITLE=Influence of acetate- vs. lactate-containing fluid bolus therapy on acid-base status, electrolytes, and plasma lactate in dogs

JOURNAL=Frontiers in Veterinary Science

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.903091

DOI=10.3389/fvets.2022.903091

ISSN=2297-1769

ABSTRACT=<sec><title>Objective</title><p>Acetate- and lactate-containing fluids influence the acid-base and electrolyte status. This prospective, randomized, clinical study compared two balanced crystalloid solutions regarding their influence on acid-base status, electrolytes, and lactate values, when given to dogs as a resuscitation bolus of 30 mL/kg.</p></sec><sec><title>Material and methods</title><p>One hundred client-owned dogs presenting to the emergency service with signs of fluid deficits were randomly assigned to receive an intravenous bolus of 30 mL/kg of either a lactate- (LAC), or an acetate-containing solution (ACET). Before and after the bolus, vital parameters were assessed, and a venous blood gas analysis was performed.</p></sec><sec><title>Results</title><p>Both solutions performed equally well in decreasing the heart rate (ACET: −10 ± 27 bpm, LAC: −12 ± 30 bpm; <italic>p</italic> = 0.737). The acetate-containing solution caused a significant decrease in plasma lactate levels (<italic>p</italic> = 0.016), anion gap (<italic>p</italic> &lt; 0.001), and potassium (<italic>p</italic> &lt; 0.001), and a significant increase in chloride (<italic>p</italic> &lt; 0.001), and ionized calcium (<italic>p</italic> = 0.014). The lactate-containing solution caused a significant decrease in anion gap (<italic>p</italic> &lt; 0.001), sodium (<italic>p</italic> = 0.016), and potassium (<italic>p</italic> = 0.001), and a significant increase in chloride (<italic>p</italic> &lt; 0.001). ACET causes a stronger decrease in plasma lactate (<italic>p</italic> = 0.015), sodium (<italic>p</italic> = 0.039), potassium (<italic>p</italic> = 0.006), and an increase in chloride (<italic>p</italic> &lt; 0.001), and ionized calcium (<italic>p</italic> = 0.016) compared to LAC.</p></sec><sec><title>Conclusion</title><p>Both solutions caused mild changes in electrolyte concentrations and had minor influence on acid-base status when used for bolus therapy in dogs with fluid deficits. Further studies are needed to evaluate their influence on acid-base status, lactate, and electrolytes when used in larger volumes and for a longer time span.</p></sec>