AUTHOR=Tu Lu , Zhao Jingjie , Chen Qiuyang , Zhang Shan , Liang Lin , Tang Xinming , Hou Shaohua , Yang Weifang , Liang Ruiying 

TITLE=Assessing the Risk of Commercial Vaccines Against Pseudorabies Virus in Cats

JOURNAL=Frontiers in Veterinary Science

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.857834

DOI=10.3389/fvets.2022.857834

ISSN=2297-1769

ABSTRACT=<p>Pseudorabies virus (PRV) is a zoonotic agent that causes significant economic losses in animal husbandry worldwide, and <italic>gE</italic>-deleted vaccines play an important role in its treatment in the swine industry. However, the potential risk of attenuated PRV strains in commercial vaccines for other hosts remains unclear. Especially, cats are important companion animals for human beings. In this study, we investigated the prevalence and pathogenicity of the PRV wild strain in the cat population. We found that the occurrence of PR diseases in cats is sporadic, that the attenuated PRV strain causes slight clinical signs in cats, and that the virus is excreted 3 days post-infection. Our findings will be beneficial in furthering our understanding of the epidemiology and pathogenicity of PRV in cats and implying the great risk of RPV transmission from pigs to cats.</p>