AUTHOR=Sun Xiaoshan , Wang Zheng , Li Xing , Du Shaohua , Lin Dongmei , Shao Yuxin 

TITLE=Effects of Yucca schidigera extract on serum biochemical parameters, humoral immune response, and intestinal health in young pigeons

JOURNAL=Frontiers in Veterinary Science

VOLUME=9

YEAR=2023

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.1077555

DOI=10.3389/fvets.2022.1077555

ISSN=2297-1769

ABSTRACT=<sec><title>Introduction</title><p>It is of great importance to find antibiotic alternatives that can improve poultry performance and enhance immunity. Plant-derived extracts and their concentrates are natural bioactive compounds that are widely and effectively applied as the antibiotic alternatives in animal industries. This study was conducted to investigate the effects of <italic>Yucca schidigera</italic> extract (YSE) on growth performance, serum biochemical parameters, immune function, intestinal morphology, and microbiota diversity of young pigeons.</p></sec><sec><title>Methods</title><p>A total of 120 healthy White King pigeons (28 days old) with similar weight were randomly assigned to 4 treatments with six replicate cages. Each of the pigeons from 4 treatments was orally administrated with 0 (control), 5, 10, and 15 mg YSE per day, respectively.</p></sec><sec><title>Results</title><p>The results showed that orally supplemental YSE had no significant effects (<italic>P</italic> &gt; 0.05) on the growth performance and immune organ index of pigeons. The serum total protein and IgM contents in the 10 mg YSE group were significantly higher (<italic>P</italic> &lt; 0.05) than those in the control group. Supplemental 10 and 15 mg YSE significantly lowered the level of serum total cholesterol (<italic>P</italic> &lt; 0.05) and increased (<italic>P</italic> &lt; 0.05) the villi height in the jejunum compared with the control group. Supplemental 5 and 10 mg YSE significantly decreased (<italic>P</italic> &lt; 0.05) the level of serum alanine aminotransferase and the crypt depth in the ileum compared with the control group. The beta diversity showed a distinct difference in the ileum microbial composition between the control and the 10 mg YES group. YSE supplementation enriched the bacterial genera <italic>Sulfurospirillum, Solobacterium, Desulfovibrio, Desulfobulbus, Lactococcus, Parabacteroides, Acidaminococcus, Acetobacter</italic>, and <italic>Streptococcus</italic>. Additionally, <italic>Enterococcus</italic> genus showed a significantly negative correlation with serum alanine aminotransferase (<italic>R</italic> = −0.618, <italic>P</italic> = 0.043). <italic>Actinomyces</italic> genus showed a significantly negative correlation with cholesterol (<italic>R</italic> = −0.633, <italic>P</italic> = 0.036). <italic>Turicibacter</italic> genus showed a significantly positive correlation with villi height in the jejunum (<italic>R</italic> = 0.751, <italic>P</italic> = 0.008).</p></sec><sec><title>Discussion</title><p>In conclusion, orally supplemental YSE could improve serum biochemistry, immunoglobulin contents, and intestinal morphology by regulating the composition of microbial community in the ileum of young pigeons.</p></sec>