AUTHOR=Xi Yu , Chen Jing , Guo Shuangshuang , Wang Sitian , Liu Zhipeng , Zheng Liyun , Qi Ya , Xu Pengtao , Li Lanlan , Zhang Zhengfan , Ding Binying 

TITLE=Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B1

JOURNAL=Frontiers in Veterinary Science

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.1037046

DOI=10.3389/fvets.2022.1037046

ISSN=2297-1769

ABSTRACT=<p>A total of 480 one-day-old AA broiler chicks were randomly allocated to one of four treatments in a 2 × 2 factorial to investigate the effects of tannic acid (TA) on growth performance, relative organ weight, antioxidant capacity, and intestinal health in broilers dietary exposed to aflatoxin B<sub>1</sub> (AFB<sub>1</sub>). Treatments were as follows: (1) CON, control diet; (2) TA, CON + 250 mg/kg TA; (3) AFB<sub>1</sub>, CON + 500 μg/kg AFB<sub>1</sub>; and (4) TA+AFB<sub>1</sub>, CON + 250 mg/kg TA + 500 μg/kg AFB<sub>1</sub>. There were 10 replicate pens with 12 broilers per replicate. Dietary AFB<sub>1</sub> challenge increased the feed conversion ratio during days 1 to 21 (<italic>P</italic> &lt; 0.05). The TA in the diet did not show significant effects on the growth performance of broilers during the whole experiment period (<italic>P</italic> &gt; 0.05). The liver and kidney relative weight was increased in the AF challenge groups compared with the CON (<italic>P</italic> &lt; 0.05). The addition of TA could alleviate the relative weight increase of liver and kidney caused by AFB<sub>1</sub> (<italic>P</italic> &lt; 0.05). Broilers fed the AFB<sub>1</sub> diets had lower activity of glutathione peroxidase, catalase, total superoxide dismutase, S-transferase, and total antioxidant capacity in plasma, liver and jejunum, and greater malondialdehyde content (<italic>P</italic> &lt; 0.05). Dietary supplemented with 250 mg/kg TA increased the activities of antioxidative enzymes, and decreased malondialdehyde content (<italic>P</italic> &lt; 0.05). In addition, AFB<sub>1</sub> significantly reduced the villus height and crypt depth ratio in the ileum on day 42 (<italic>P</italic> &lt; 0.05). In conclusion, supplementation with 250 mg/kg TA could partially protect the antioxidant capacity and prevent the enlargement of liver in broilers dietary challenged with 500 μg/kg AFB<sub>1</sub>.</p>