AUTHOR=Zhang Lei , Wang Fenghong , Gao Gong , Yan Xiaochun , Liu Hongfu , Liu Zhihong , Wang Zhixin , He Libing , Lv Qi , Wang Zhiying , Wang Ruijun , Zhang Yanjun , Li Jinquan , Su Rui 

TITLE=Genome-Wide Association Study of Body Weight Traits in Inner Mongolia Cashmere Goats

JOURNAL=Frontiers in Veterinary Science

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2021.752746

DOI=10.3389/fvets.2021.752746

ISSN=2297-1769

ABSTRACT=<p><bold>Objective:</bold> Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth weight (BW), weaning weight (WW), and yearling weight (YW).</p><p><bold>Materials and Methods:</bold> In this study, a genome-wide association study (GWAS) of BW, WW, and YW was determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats.</p><p><bold>Results:</bold> We discovered that 21 SNPs were significantly associated with BW on the genome-wide levels. These SNPs were located in 10 genes, e.g., Mitogen-Activated Protein Kinase 3 (<italic>MAPK3</italic>), LIM domain binding 2 (<italic>LDB2</italic>), and low-density lipoprotein receptor-related protein 1B (<italic>LRP1B</italic>), which may be related to muscle growth and development in Inner Mongolia Cashmere goats. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that these genes were significantly enriched in the regulation of actin cytoskeleton and phospholipase D signaling pathway etc.</p><p><bold>Conclusion:</bold> In summary, this study will improve the marker-assisted breeding of Inner Mongolia cashmere goats and the molecular mechanisms of important economic traits.</p>