AUTHOR=Kucková Katarína , Grešáková L'ubomíra , Takácsová Margaréta , Kandričáková Anna , Chrastinová L'ubica , Polačiková Mária , Cieslak Adam , Ślusarczyk Sylwester , Čobanová Klaudia 

TITLE=Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract

JOURNAL=Frontiers in Veterinary Science

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2021.740658

DOI=10.3389/fvets.2021.740658

ISSN=2297-1769

ABSTRACT=<p>This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly assigned to one of four treatment groups: a control group (C), a Zn group supplemented with dietary zinc (50 mg/kg), a TE group receiving thyme extract applied in drinking water (1 ml/L), and a Zn + TE group treated with both additives. Lipid peroxidation in the plasma was influenced by Zn intake and in the kidney was affected by both the Zn and TE treatment (<italic>P</italic> &lt; 0.05). Zn supplementation led to a significant increase in glutathione peroxidase activity (<italic>P</italic> = 0.017), total antioxidant capacity (<italic>P</italic> = 0.009) and total thiol groups level (<italic>P</italic> = 0.047) in the kidney, with the highest values occurring in rabbits receiving the combination Zn + TE. Administration of TE influenced Zn content in the kidney (<italic>P</italic> &lt; 0.001), while zinc intake decreased Cu concentration in muscle (<italic>P</italic> = 0.021). In conclusion, the simultaneous administration of organic Zn and TE positively affected the antioxidant response of kidneys and can be used for improving the antioxidant status of growing rabbits.</p>