AUTHOR=Vangone Lucia , Cardillo Lorena , Riccardi Marita Georgia , Borriello Giorgia , Cerrone Anna , Coppa Paolo , Scialla Roberto , Sannino Emanuela , Miletti Gianluca , Galiero Giorgio , Fusco Giovanna 

TITLE=Mycobacterium tuberculosis SIT42 Infection in an Abused Dog in Southern Italy

JOURNAL=Frontiers in Veterinary Science

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2021.653360

DOI=10.3389/fvets.2021.653360

ISSN=2297-1769

ABSTRACT=<p>A case of <italic>Mycobacterium tuberculosis</italic> infection is described in a dead adult male dog in Southern Italy. The carcass was found by the Health Authority in a gypsy encampment. It was admitted to our forensic veterinary medicine unit, with a suspicion of cruelty to the animal. Necropsy showed beating and traumatism signs, and mistreating was confirmed. Gross lesions included multiple nodular hepatic lesions, hemorrhagic enteritis with enlarged mesenteric lymph nodes, body cavity effusions, and an adrenal neoplasm. Bacteriological and molecular analyses were carried out on the liver lesions that enabled to identify <italic>M. tuberculosis</italic> SIT42 (LAM9). Drug-resistance patterns were evaluated by screening mutations on the <italic>rpoB</italic> and <italic>katG</italic> genes that showed susceptibility to both rifampin and isoniazid, respectively. Very few studies report canine tuberculosis, and little is known about the disease in Italy. To the authors' knowledge, this is the first report of <italic>Mycobacterium tuberculosis</italic> SIT42 infection in a dog in Italy.</p>