AUTHOR=Reyes-Camacho David , Pérez José Francisco , Vinyeta Ester , Aumiller Tobias , Criado-Mesas Lourdes , Folch Josep Maria , Van der Klis Jan Dirk , Solà-Oriol David 

TITLE=Phytogenic Compounds Supplemented to Gestating Hyperprolific Sows Affects the Gut Health-Related Gene Expression and Histological Responses in Neonate Piglets

JOURNAL=Frontiers in Veterinary Science

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2021.639719

DOI=10.3389/fvets.2021.639719

ISSN=2297-1769

ABSTRACT=<p>This research aims to determine whether a specific blend of phytogenic compounds (BPC) supplemented in gestating hyperprolific sow diets can promote prenatal maternal effects in terms of piglet gut function and morphology. Twenty-eight (Landrace × Yorkshire) gilts and sows (parity 0 to 7) were randomly distributed by parity number and body weight into two dietary treatments: unsupplemented Control (CON) (<italic>n</italic> = 14) or CON diet supplemented with 1 g/kg feed of BPC during gestation (<italic>n</italic> = 14). The BPC supplementation during gestation of sows downregulated the neonate piglets' jejunal genes involved in oxidation (<italic>SOD2</italic>) and nutrient transport (<italic>SLC16A1/MCT1, SLC11A2/DMT1</italic>, and <italic>SLC39A/ZIP4</italic>), while <italic>IFNG</italic> and <italic>CLDN4</italic> related to immune response and barrier function, respectively, were upregulated (<italic>q</italic> &lt; 0.10). In addition, the jejunal villus height and the ratio of the villus height to crypt depth tended to increase (<italic>p</italic> &lt; 0.10), while goblet cell volume density was higher (<italic>p</italic> &lt; 0.05) in BPC compared to CON. In conclusion, dietary supplementation of BPC in gestating diets for hyperprolific sows influences neonatal histomorphology and expression of genes related to the intestinal function and health.</p>