AUTHOR=Plasencia-Muñoz Berenice , Avelar-González Francisco J. , De la Garza Mireya , Jacques Mario , Moreno-Flores Adriana , Guerrero-Barrera Alma L. 

TITLE=Actinobacillus pleuropneumoniae Interaction With Swine Endothelial Cells

JOURNAL=Frontiers in Veterinary Science

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2020.569370

DOI=10.3389/fvets.2020.569370

ISSN=2297-1769

ABSTRACT=<p><italic>Actinobacillus pleuropneumonia</italic> is a swine (host) specific respiratory pathogen and the etiological agent of swine pleuropneumonia which affects pigs of all ages, many being asymptomatic carriers. This pathogen has high morbidity and mortality rates which generates large economic losses for the pig industry. Actinobacillus pleuropneumoniae is a widely studied bacterium, however its pathogenesis is not yet fully understood. The prevalence of the 18 serotypes of <italic>A. pleuropneumoniae</italic> varies by geographic region, in North American area, more specifically in Mexico, serotypes 1, 3, 5b, and 7 show higher prevalence. <italic>Actinobacillus pleuropneumoniae</italic> is described as a strict extracellular pathogen with tropism for lower respiratory tract. However, this study depicts the ability of these serotypes to adhere to non-phagocytic cells, using an endothelial cell model, as well as their ability to internalize them, proposing it could be considered as an intracellular pathogen.</p>