AUTHOR=Kalil Mauricio Alcântara , Santos Laerte Marlon , Barral Thiago Doria , Rodrigues Daniela Méria , Pereira Neila Paula , Sá Maria da Conceição Aquino , Umsza-Guez Marcelo Andres , Machado Bruna Aparecida Souza , Meyer Roberto , Portela Ricardo Wagner TITLE=Brazilian Green Propolis as a Therapeutic Agent for the Post-surgical Treatment of Caseous Lymphadenitis in Sheep JOURNAL=Frontiers in Veterinary Science VOLUME=6 YEAR=2019 URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2019.00399 DOI=10.3389/fvets.2019.00399 ISSN=2297-1769 ABSTRACT=
As antibiotics are ineffective when used to treat caseous lymphadenitis, the surgical excision of lesions is often required. Iodine solution (10%) is currently the choice for the post-surgical treatment; however, it may cause histotoxicity. Propolis are resinous substances composed by a mixture of different plants parts and molecules secreted by bees. As green propolis has already proven to possess anti-bacterial and wound healing properties, this study aimed to evaluate the use of a green propolis-based ointment as a therapeutic agent for the post-surgical treatment of caseous lymphadenitis. The caseous lesions of 28 sheep were surgically excised before dividing animals into two groups: (1) iodine-treated animals and (2) sheep treated with an ointment made with a previously characterized green propolis extract. Clinical data of animals, size of the scar area, the presence of moisture and secretion in the surgical wound, the humoral immune response against the bacterium and the susceptibility of