AUTHOR=Bascuñán Ana Luisa , Biedrzycki Adam , Banks Scott A. , Lewis Daniel D. , Kim Stanley E. 

TITLE=Large Animal Models for Anterior Cruciate Ligament Research

JOURNAL=Frontiers in Veterinary Science

VOLUME=6

YEAR=2019

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2019.00292

DOI=10.3389/fvets.2019.00292

ISSN=2297-1769

ABSTRACT=<p>Large animal (non-rodent mammal) models are commonly used in ACL research, but no species is currently considered the gold standard. Important considerations when selecting a large animal model include anatomical differences, the natural course of ACL pathology in that species, and biomechanical differences between humans and the chosen model. This article summarizes recent reports related to anatomy, pathology, and biomechanics of the ACL for large animal species (dog, goat, sheep, pig, and rabbit) commonly used in ACL research. Each species has unique features and benefits as well as potential drawbacks, which are highlighted in this review. This information may be useful in the selection process when designing future studies.</p>