AUTHOR=Selimovic-Hamza Senija , Bouzalas Ilias G. , Vandevelde Marc , Oevermann Anna , Seuberlich Torsten 

TITLE=Detection of Astrovirus in Historical Cases of European Sporadic Bovine Encephalitis, Switzerland 1958–1976

JOURNAL=Frontiers in Veterinary Science

VOLUME=3

YEAR=2016

URL=https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2016.00091

DOI=10.3389/fvets.2016.00091

ISSN=2297-1769

ABSTRACT=<p>European sporadic bovine encephalitis is a frequent diagnosis in neurologically diseased cattle, but its etiology remained unresolved. Using <italic>in situ</italic> hybridization, we have detected a recently discovered neurotropic bovine astrovirus in historical tissues in a high proportion of brain samples of affected cattle. Our results suggest that astroviruses were already involved in the pathogenesis of the disease several decades ago, but have gone undetected.</p>