Qianhao Huang ¹ Dongfeng Xiong ^1,2 Yifan Huang ^1,2 Xuan Zhuang ^1,2* Yuedong Chen ^1,2*

• ¹ The Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China 361003, Xiamen, China
• ² The School of Clinical Medicine, Fujian Medical University, Fuzhou, China,350122, Xiamen, Fujian Province, China

Sarcomatoid carcinoma of the penis, also known as carcinosarcoma, is a rare form of squamous cell carcinoma of the penis, accounting for approximately 1-2% of all penile cancers. A 60-year-old male patient presented with glans nodules and evidence of metastatic disease to the bilateral inguinal lymph nodes and the left pelvic lymph node. He underwent a partial resection and bilateral inguinal and pelvic lymph node dissection. Histopathology demonstrated that the tumour cells were p63-positive, while p16 expression was absent. Vimentin and p53 were positive in the sarcomatous component, and the morphology and immunohistochemistry were consistent with penile sarcomatoid carcinoma. One week later, the patient was found to have thrombosis of the right common iliac vein. After six months, there was no evidence of disease progression. The diagnosis of sarcomatoid carcinoma is challenging, and an accurate diagnosis is the first step towards successful treatment, which has a higher probability of success. Key words: sarcomatoid carcinoma, penile cancer, penectomy human papillomavirus HPV computed tomography (CT) CT magnetic resonance imaging (MRI) MRISquamous cell carcinoma SCC