AUTHOR=Aksu Bagdagul , Afonso Alberto Caldas , Akil Ipek , Alpay Harika , Atmis Bahriye , Aydog Ozlem , Bakkaloglu Sevcan , Bayazıt Aysun Karabay , Bayram Meral Torun , Bilge Ilmay , Bulut Ipek Kaplan , Cetinkaya Ayse Pinar Goksu , Comak Elif , Demir Belde Kasap , Dincel Nida , Donmez Osman , Durmus Mehmet Akif , Dursun Hasan , Dusunsel Ruhan , Duzova Ali , Ertan Pelin , Gedikbasi Asuman , Goknar Nilufer , Guven Sercin , Hacihamdioglu Duygu , Jankauskiene Augustina , Kalyoncu Mukaddes , Kavukcu Salih , Kenan Bahriye Uzun , Kucuk Nuran , Kural Bahar , Litwin Mieczysław , Montini Giovanni , Morello William , Obrycki Lukasz , Omer Beyhan , Misirli Ozdemir Ebru , Ozkayin Nese , Paripovic Dusan , Pehlivanoglu Cemile , Saygili Seha , Schaefer Franz , Schaefer Susanne , Sonmez Ferah , Tabel Yilmaz , Tas Nesrin , Tasdemir Mehmet , Teixeira Ana , Tekcan Demet , Topaloglu Rezan , Tulpar Sebahat , Turkkan Ozde Nisa , Uysal Berfin , Uysalol Metin , Vitkevic Renata , Yavuz Sevgi , Yel Sibel , Yildirim Tarik , Yildirim Zeynep Yuruk , Yildiz Nurdan , Yuksel Selcuk , Yurtseven Eray , Yilmaz Alev TITLE=The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study JOURNAL=Frontiers in Urology VOLUME=3 YEAR=2024 URL=https://www.frontiersin.org/journals/urology/articles/10.3389/fruro.2023.1281081 DOI=10.3389/fruro.2023.1281081 ISSN=2673-9828 ABSTRACT=Background

Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.

Methods

Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).

Results

uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).

Conclusion

Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.