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BRIEF RESEARCH REPORT article

Front. Tuberc
Sec. Epidemiology of Tuberculosis
Volume 2 - 2024 | doi: 10.3389/ftubr.2024.1433975

Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts

Provisionally accepted
Sonya Krishnan Sonya Krishnan 1*Nikhil Gupte Nikhil Gupte 2Mandar Paradkar Mandar Paradkar 2Akshay Gupte Akshay Gupte 3Mrunmayi Naik Mrunmayi Naik 2Swapnil Raskar Swapnil Raskar 2Nishi Suryavanshi Nishi Suryavanshi 2Neeta Pradhan Neeta Pradhan 2Sanjay Gaikwad Sanjay Gaikwad 4Rajesh Karyakarte Rajesh Karyakarte 4Rahul Lokhande Rahul Lokhande 4Elizabeth Hanna Luke Elizabeth Hanna Luke 5Kannan Thiruvengadam Kannan Thiruvengadam 5Padmapriyadarsini Chandrasekaran Padmapriyadarsini Chandrasekaran 5Tushar Sahasrabudhe Tushar Sahasrabudhe 6Madhusudan Barthwal Madhusudan Barthwal 6Arjunlal Kakrani Arjunlal Kakrani 6Vijay Viswanathan Vijay Viswanathan 7Hardy Kornfeld Hardy Kornfeld 8Amita Gupta Amita Gupta 2,9Jonathan Golub Jonathan Golub 10Vidya Mave Vidya Mave 2,9
  • 1 Johns Hopkins Medicine, Johns Hopkins University, Baltimore, United States
  • 2 Johns Hopkins University Clinical Research Site, Byramjee-Jeejeebhoy Government Medical College, Pune, Maharashtra, India
  • 3 Department of Global Health, School of Public Health, Boston University, Boston, Massachusetts, United States
  • 4 Byramjee Jeejeebhoy Government Medical College-Sassoon Government Hospital, Pune, Maharashtra, India
  • 5 National Institute of Research in Tuberculosis (ICMR), Chennai, Tamil Nadu, India
  • 6 Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India
  • 7 M.V. Hospital for Diabetes, Chennai, Tamil Nadu, India
  • 8 Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States
  • 9 School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States
  • 10 Center for Tuberculosis Research, Johns Hopkins University, Baltimore, Maryland, United States

The final, formatted version of the article will be published soon.

    Some individuals with drug-susceptible pulmonary tuberculosis (PTB) experience tuberculosis recurrence. To evaluate the incidence of and risk factors for recurrence following completion of antituberculosis therapy, we pooled data from three prospective observational Indian PTB cohorts with 1164 individuals 14 years old included in our analysis. Ninety-five (8%) experienced recurrence with an 8.5 cases/100 person-years recurrence incidence rate (95% confidence interval 6.9-10.3) and a median time to recurrence of 6 months. On multivariable logistic regression, month 2 culture positivity (aHR 2.06; 95% CI 1.17-3.63), BMI <17 mg/kg 2 (aHR 1.7; 95% CI 1.1-2.8), and male sex (aHR 1.92; 95% CI 1.05-3.51) were independent recurrence risk factors. Understanding risk factors for TB recurrence could enable clinicians to identify patients at risk for recurrence during antituberculosis therapy and may be used to alter patient care strategies, such as more frequent monitoring post treatment for high-risk individuals.

    Keywords: Tuberculosis, Recurrence, Risk factors, Adverse outcome, EPI - epidemiology

    Received: 16 May 2024; Accepted: 27 Jun 2024.

    Copyright: © 2024 Krishnan, Gupte, Paradkar, Gupte, Naik, Raskar, Suryavanshi, Pradhan, Gaikwad, Karyakarte, Lokhande, Hanna Luke, Thiruvengadam, Chandrasekaran, Sahasrabudhe, Barthwal, Kakrani, Viswanathan, Kornfeld, Gupta, Golub and Mave. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sonya Krishnan, Johns Hopkins Medicine, Johns Hopkins University, Baltimore, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.