AUTHOR=Molina-Moya Bárbara , Villar-Hernández Raquel , Ciobanu Nelly , Muriel-Moreno Beatriz , Lacoma Alicia , Codreanu Alexandru , Latorre Irene , Smalchuk Daria , Prat-Aymerich Cristina , Crudu Valeriu , Kontogianni Konstantina , Cuevas Luis E. , Domínguez José 

TITLE=Acute phase proteins and IP-10 in plasma for tuberculosis diagnosis

JOURNAL=Frontiers in Tuberculosis

VOLUME=1

YEAR=2023

URL=https://www.frontiersin.org/journals/tuberculosis/articles/10.3389/ftubr.2023.1267221

DOI=10.3389/ftubr.2023.1267221

ISSN=2813-7868

ABSTRACT=<sec><title>Background</title><p>Tuberculosis (TB) is a leading cause of death from a single infectious agent, and triage tests based on biomarkers may help to improve the diagnosis. This study aims to determine whether C-reactive protein (CRP), interferon-γ-inducible protein 10 (IP-10), α1-acid glycoprotein (AGP), and α1-anti-trypsin (AAT) could be useful for a screening test in patients with presumptive TB disease.</p></sec><sec><title>Methods</title><p>CRP, IP-10, AGP, and AAT were measured in plasma samples from 277 patients with presumptive TB disease in the Republic of Moldova in a prospective study.</p></sec><sec><title>Results</title><p>In general, the levels of all the biomarkers were higher in patients with TB than in the other groups (<italic>p</italic> &lt; 0.05). Receiver operating characteristic curve analyses showed an area under the curve lower than 0.7 for all the biomarkers, and low correlations (Spearman's <italic>r</italic> &lt; 0.6) were found between biomarkers.</p></sec><sec><title>Conclusion</title><p>The levels of the tested biomarkers were different throughout the patient groups studied, but their suboptimal diagnostic performance either as individual biomarkers or in combination does not favor their use for triage testing.</p></sec>