METHODS article
Front. Trop. Dis.
Sec. Disease Prevention and Control Policy
Volume 6 - 2025 | doi: 10.3389/fitd.2025.1571116
This article is part of the Research TopicChallenges in reaching the UNAIDS 95-95-95 targets in Sub-Saharan Africa: Status, innovations, and pathways forwardView all 9 articles
Validation of a model for predicting HIV pre-exposure prophylaxis (PrEP) uptake: A study protocol.
Provisionally accepted
- 1Kibabii University, Bungoma, Kenya
- 2Moi University, Eldoret, Kenya
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Introduction: By 2023, HIV will have claimed 40.4 million lives, posing a significant global public health risk, with youth at the highest risk of new infections. Pre-exposure prophylaxis (PrEP) reduces HIV transmission by 48.9% when combined with other prevention strategies. Despite increased PrEP programs in sub-Saharan Africa since 2015, uptake remains low due to various barriers. This study aims to validate a model identifying demographic, economic, social, behavioral, and structural factors influencing PrEP use in Turbo Sub-County, where uptake is among the lowest.The study will employ a descriptive cross-sectional design using both quantitative and qualitative methods to gather data from youths aged 15-24 in Turbo Sub-County. Participants will be selected through multistage random sampling based on Wards and villages. Data will be collected via self-administered questionnaires, interviews, and Focus Group Discussions (FGDs). Analysis will include thematic methods for qualitative data and Structural Equation Modeling (SEM) will be used to validate the relationships predicting PrEP uptake at 95% confidence intervals and α < 0.05.The study is expected to provide insights into factors influencing PrEP uptake among youths in Turbo Sub-County. The validated model will highlight key demographic, economic, and behavioral determinants, offering actionable data for enhancing HIV prevention strategies tailored to this population.Discussion: The discussion will interpret the interplay of factors affecting PrEP uptake and compare findings with regional studies. It will emphasize community-specific barriers and enablers, informing targeted interventions and strategies to improve PrEP accessibility and acceptance.The study aims to provide a validated framework for predicting PrEP uptake, guiding stakeholders in addressing barriers and strengthening interventions. The findings will support optimizing PrEP programs to reduce HIV transmission among at-risk youth.
Keywords: HIV prevention and control, Validated model, Pre exposure prophylaxis (PrEP), structural equation modeling (SEM), Kenya
Received: 05 Feb 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Shisanya and Kileku. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Morris Senghor Shisanya, Kibabii University, Bungoma, Kenya
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