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MINI REVIEW article
Front. Transplant.
Sec. Abdominal Transplantation
Volume 4 - 2025 | doi: 10.3389/frtra.2025.1576549
This article is part of the Research Topic Decedent Model vs Primate Model - Do We Know Enough? View all 3 articles
Pre-clinical Xenotransplantation: Physiology and Pharmacy in Human Decedent and Non-human Primate Models
Provisionally accepted
Douglas J Anderson 1*
Jayme E Locke 2- 1 University of Alabama at Birmingham, Birmingham, United States
- 2 NYU Langone Health, New York, United States
Non-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the xenograft in a human decedent or non-human primate. Additionally, we will discuss the pharmacologic agents typically employed in each model, highlighting both the ability of the decedent model to test clinically-relevant medication strategies that may be impossible in non-human primates due to species-specificity.
Keywords: Xenotransplant, Kidney, renal physiology, pharmacokinetics, non-human primate, decedent model
Received: 14 Feb 2025; Accepted: 28 Mar 2025.
Copyright: © 2025 Anderson and Locke. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Douglas J Anderson, University of Alabama at Birmingham, Birmingham, United States
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