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CASE REPORT article
Front. Transplant.
Sec. Abdominal Transplantation
Volume 4 - 2025 | doi: 10.3389/frtra.2025.1576301
This article is part of the Research Topic Organ Transplantation by 2040 View all 3 articles
“ABO incompatible living donor Liver transplantation in a patient with associated Rosai-Dorfman-Destombes disease, first reported case.”
Provisionally accepted- Fortis hospital, Noida, Noida, India
Rosai-Dorfman-Destombes disease (RDD), a rare histiocytic proliferation, is often associated with lymphadenopathy and extra-nodal manifestations, including involvement of the liver. We report a unique case of RDD presenting with chronic liver disease (CLD) in a 7-year-old boy, highlighting the association between these conditions. The patient underwent ABO-incompatible living donor liver transplantation (LDLT), a procedure not previously documented in the context of RDD. Successful transplantation was preceded by a desensitization protocol including rituximab and immunoadsorption, and was followed by a satisfactory postoperative course. This case underscores the need for further investigation into the relationship between RDD and CLD and the potential of LDLT as a life-saving treatment option in such complex cases.
Keywords: RDD = Rosai-Dorfman disease, ABOi, ABO incompatible, LDLT and DDLT, CLD (Chronic liver disease)
Received: 13 Feb 2025; Accepted: 21 Mar 2025.
Copyright: © 2025 Sahoo, Makki, Saini, Srivastava and Vij. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bhabani Sankar Sahoo, Fortis hospital, Noida, Noida, India
Vivek Vij, Fortis hospital, Noida, Noida, India
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